丹尼尔米. Stoebel

丹Stoebel

生物学教授

F.W. 奥林科学中心2364室
1250 N. 达特茅斯大街.
Claremont, CA 91711
909.607.1141
stoebel@g.xingda-dk.com

Education and Professional Experience

  • B.A.波莫纳学院生物学专业
  • PhD, Ecology and Evolution, Stony Brook University
  • Postdoctoral 研究 Fellow, Trinity College, University of Dublin
  • Postdoctoral 研究 Fellow, University of Houston

教学的兴趣

My teaching interests span molecular and evolutionary genetics, 从一年级到高年级, 在实验室, 研讨会, 讲座设置. I also take great pleasure teaching statistics and courses at the interface of biology and the humanities.

在过去的几年里，我教过:

  • Bio 52: Introduction to 生物学
  • Bio 54: Introductory 生物学 Lab
  • 生物113:分子遗传学
  • 生物统计学
  • 生物164:遗传学
  • Bio/Chem 189: Current Topics in 分子生物学 and Biochemistry
  • 历史 179J: 遗传学 and Race
  • Writing 1: Introduction to Academic Writing

研究兴趣

Work in my lab focuses on the molecular biology and evolution of bacterial regulatory networks. 的 E. 杆菌 global transcription regulator RpoS is the focus of work, because it allows for the integration of molecular biology, 生理与进化. Projects include studying how RpoS levels vary across strains and environments, measuring the affect of this variation in RpoS level on the transcriptome, studying how RpoS interacts with other transcription factors to influence patterns of transcription, and exploring how the regulation of RpoS levels varies in pathogenic relatives of laboratory E. 杆菌.

I encourage students at HMC or any of the other Claremont Colleges for whom this sounds interesting to contact me. I regularly invite students of all backgrounds into my lab.

选定的出版物

(* indicates work done as an undergraduate)

Adams, Josephine*, Johnson Hoang*, Emily Petroni*, Ethan Ashby*, Johanna 哈丁, 丹尼尔米. Stoebel. “的 timing of transcription of RpoS-dependent genes varies across multiple stresses in 大肠杆菌 K-12.” mSystems, 8: e0066323. http://doi.org/10.1128/msystems.00663-23

Beck, Christina*, Sayde Perry*, 丹尼尔米. Stoebel和简·M. 刘. “Cra and CRP have opposing roles in the regulation of FruB in 霍乱弧菌.” 细菌学杂志, 203:e00044-21. http://doi.org/10.1128/JB.00044-21

史蒂芬·菲茨杰拉德，史蒂芬尼·C. 凯里，埃布蒂哈尔. Keith D . Alshabib. 麦肯齐, 丹尼尔米. Stoebel，赵子超，张德华. S. 卡梅隆. “Redefining the H-NS protein family: a diversity of specialized core and accessory forms exhibit hierarchical transcriptional network integration.” 2020. 核酸研究 48: 10184–98. http://doi.org/10.1093/nar/gkaa709

汉密尔顿，费雯，还有 丹尼尔. M. Stoebel. 2020. 历史 in the education of scientists: encouraging judgment and social action. 伊西斯 111: 623–30. http://doi.org/10.1086/711101

布什,E. C., A. E. 克拉克* C. A. DeRanek *,. Eng *, J. 福尔曼* K. 希斯*,. B. 李*, D. M. Stoebel, Z. 王*,米. 威尔伯*和H. Wu*. 2018. xenoGI: Reconstructing the history of genomic island insertions in clades of closely related bacteria. BMC生物信息学, 19:32. doi: 10.1101/188599

G. T. 黄* R. P. Bonocora,. N. Schep *,年代. M. 分为上下*,. J. 李方，L. M. Shull * L. E. Batachari *,米. 狄龙* C. J. 贝克尔* C. 埃文斯* E. C. 布什,J. 哈丁,J. T. 韦德, D. M. Stoebel. 2017. 的 genome-wide transcriptional response to varying RpoS levels in 大肠杆菌 K-12. 细菌学杂志, 199: e00755-16. doi: 10.1128/JB.00755-16.

C. 埃文斯*,J. 哈丁, D. M. Stoebel. 2017. Selecting between-sample RNA-Seq normalization methods from the perspective of their assumptions. 生物信息学简介. doi: 10.1093 /龙头/ bbx008.

Y. 王,C. D. 领域, D. M. Stoebel, K. 弗林,E. 纳普米. M. 狄龙,. 希望,P. J. 孵卵器,F. B.-G. 摩尔,V. S. 库珀和T. F. 库珀. 2016. Benefit of transferred mutations is better predicted by the fitness of recipients than by their ecological or genetic relatedness. PNAS, 113:5047-5052.

E. 斯奈德* D. M. 戈登, D. M. Stoebel. 2012. 大肠杆菌 缺乏rpo are rare in natural populations of non-pathogens. G3:基因|基因组 | 遗传学, 2:1341-4

Stoebel D. M. & C. J. 多尔曼. 2010. 的 effect of mobile element IS10 on experimental regulatory evolution in 大肠杆菌. 分子生物学与进化, 27: 2105-2112.

Stoebel D. M., K. Hokamp, M. S. 最后的 & C. J. 多尔曼. 2009. Compensatory evolution of gene regulation in response to stress by E. 杆菌 缺乏rpo. 公共科学图书馆遗传学 5: e1000671

Stoebel D. M., A. 免费的 & C. J. 多尔曼. 2008. Anti-silencing: overcoming H-NS-mediated repression of transcription in Gram-negative enteric bacteria. 微生物学, 154: 2533-2545.

Stoebel D. M., A. M. 迪安 & D. E. Dykhuizen. 2008. 的表达成本 大肠杆菌 虫胶 operon proteins is in the process, not in the products. 遗传学, 178:1653-1660.

Stoebel D. M. 2005. Lack of evidence for horizontal transfer of the 虫胶 操纵子进 大肠杆菌. 分子生物学与进化, 22:683-690.